Frontispiece: The Deuterated “Magic Methyl” Group: A Guide to Site‐Selective Trideuteromethyl Incorporation and Labeling by Using CD 3 Reagents
نویسندگان
چکیده
Profound pharmacological benefits can be provided by site-selective incorporation of the deuterated “magic methyl” group, which considered an important tool for drug optimization and development. This review highlights trideuteromethylation strategies according to reagent used describes mechanism scope reactions. As such, this aims a guide researchers, offering them available C−CD3 formation preparation new or modified drugs materials. For more details see Review M. Rueping et al. on page 11751 ff.
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ژورنال
عنوان ژورنال: Chemistry: A European Journal
سال: 2021
ISSN: ['0947-6539', '1521-3765']
DOI: https://doi.org/10.1002/chem.202184661